UC Davis Medical Center - Cypress Building
2221 Stockton Blvd., Suite E
Sacramento, CA 95817
Additional Phone Numbers
Philosophy of Care
I believe in providing compassionate and expert care for my patients to obtain optimal outcomes and relief from their problems. I rely on current, data-driven best practices for my surgical recommendations as well as the rich expertise of my colleagues and mentors to ensure my patients do well.
I strive to listen thoroughly and communicate clearly to explain my clinical reasoning and recommendations so that patients completely understand their options and what to expect. I treat my patients with the same respect and kindness as I would want my own family to receive.
Dr. Lyo specializes in minimally invasive (laparoscopic and robotic) and traditional open techniques to address obesity, foregut diseases such as GERD, achalasia, and hiatal hernias, as well as abdominal wall and groin hernias, and gallbladder disease.
She is fellowship-trained in minimally invasive surgery and has expertise in:
- Foregut: esophageal dilation and stenting, Heller myotomy for achalasia, anti-reflux procedures, hiatal hernias, gastric fundoplications and gastric resection, feeding tube placement, gastroparesis
- Bariatrics: gastric bypass, sleeve gastrectomy, revisional/redo surgery
- Hernia: complex abdominal wall reconstruction, component separation, groin hernias
- Biliary: gallbladder removal, bile duct exploration, laparoscopic-assisted ERCP
Dr. Lyo's research focuses on understanding the interactions between the gut microbiome and human host, specifically on how the microbiome contributes to obesity and wound healing. By better understanding this area, she aims to improve the management of obesity and outcomes after bariatric and hernia surgery.
Dr. Lyo has an extensive biomedical research background and holds a Master degree in Translational Medicine from UC Berkeley and UCSF. She is committed to developing innovative devices and products to bring into clinical practice.
Foregut and Endometabolic Surgery
M.D. with Distinction, University of California San Francisco, San Francisco CA 2001
M.T.M., University of California Berkeley & San Francisco, Berkeley and San Francisco CA 2015
B.A., Wellesley College, Wellesley MA 2001
Internship: University of California San Francisco, San Francisco CA 2011-2012
General Surgery, University of California San Francisco, San Francisco CA 2012-2018
Advanced GI and Minimally Invasive Surgery, Oregon Health & Science University, Portland OR 2018-2019
American Board of Surgery - General Surgery,
da Vinci Robotic Platform Certified,
American College of Surgeons
American Society for Metabolic and Bariatric Surgery
Association of Women Surgeons
Naffziger Surgical Society
Society of American Gastrointestinal and Endoscopic Surgeons
Society of Asian Academic Surgeons
Honors and Awards
Pacific Northwest American College of Surgeons Bruce Wolfe Bariatric Research Award, 2019
UC San Francisco Lawrence Way Critical Thinking Award, 2018
UC San Francisco Dean's Prize in Research Award, 2011
Pancreas Club Best Oral Presentation Research Award, 2010
Howard Hughes Medical Institute Medical Research Fellowship, 2009, 2010
Select Recent Publications
Lyo V, Schafer A, Stewart L. Roux-en-Y Gastric Bypass is a Safe and Effective Option that Improves Major Co-Morbidities Associated with Obesity in an Older, Veteran Population. Am J Surg. Epub ahead of print. 2019.
Brown I, Bellevue O, Shawo A, Woldesemayat H, Lyo V, Rayikanti B, Lee M, Uzosike ED, Kasravi S, Harris HW. Low Dose Cyclophosphamide Improves Survival in a Murine Treatment Model of Sepsis. Shock. 2015;43(1):92-8.
Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Gottrell GS, Bogyo M, Knecht W, Bunnett NW. Serine Proteases and Protease-activated Receptor 2 Mediate the Proinflammatory and Algesic Actions of Diverse Stimulants. Br J Pharmacol. 2014;171(16): 3814-26.
Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU. The TGR5 Receptor Mediates Bile Acid-Induced Itch and Analgesia. J Clin Invest. 2013;123(4):1513-30.
Lyo V, Cattaruzza F, Kim T, Paulick MG, Cox D, Cloyd J, Buxbaum J, Ostroff J, Bogyo M, Grady EF, Bunnett NW, Kirkwood KS. Active cathepsins B, L, and S in murine and human pancreatitis. Amer J Physiol Gastrointest Liver Physiol. 2012;303(8):G894-903.
Lyo V, Jaigirdar AA, Thummala S, Morita ET, Treseler PA, Kashani-Sabet M, Leong SPL. In-transit Intramammary Sentinel Lymph Nodes from Malignant Melanoma of the Trunk. Ann. Surg. 2012;255(1):122-7.
Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, Valdez-Morales E, Ibeakanma C, Vanner SJ, Bogyo M, Bunnett NW. Cathepsin S is Activated During Colitis and Causes Visceral hyperalgesia by a PAR2-dependent Mechanism in Mice. Gastroenterology. 2011;141(5):1864-74.
Ceppa EP, Lyo V, Knecht W, Petersen A, Grady EF, Grahn S, Bunnett NW, Kirkwood KS, Cattaruzza F. Serine Proteases Mediate Inflammatory Pain in Acute Pancreatitis. Amer J Physiol Gastrointest Liver Physiol. 2011;300 (6):G1033-42.
Ceppa E, Cattaruzza F, Lyo V, Amadesi S, Vaksman N, Liedtke W, Cohen DM, Grady EF, Bunnett NW, Kirkwood KS. Transient Receptor Potential Ion Channels V4 and A1 Mediate Pancreatitis Pain in Mice. Amer J Physiol Gastrointest Liver Physiol. 2010;299(3):G556-71.
Hood-DeGrenier JK, Boulton, CN, Lyo, V. Cytoplasmic Clb2 is required for timely inactivation of the mitotic inhibitor Swe1 and normal bud morphogenesis in Saccharomyces cerevisiae. Curr Genet. 2007;51:1-18.